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E-Source / e-TMF

# Application
Last updated: 04/14/2026

Business definition of E-Source and e-TMF — trial documentation and electronic Trial Master File management.

What it is

E-Source and the electronic Trial Master File (e-TMF) manage trial documentation in a centralized, audit-ready repository. E-Source links source documentation to clinical data; e-TMF provides the filing structure, document types, and access control expected for regulatory Trial Master File management.

Who uses it

RoleTypical use
Study Administrator / TMF ManagerConfigure document types, filing structure, and access
CRA / MonitorUpload and review site and study-level TMF documents
Site staffFile source documents and study correspondence
SponsorOversight of TMF completeness and inspection readiness

Key capabilities

  • Configurable TMF document types and folder structure
  • Document upload, versioning, and access control
  • Integration with source data and CRF attachments
  • Audit trail for document lifecycle events
ApplicationE-Sourcee-TMFTMF
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